MOTS-C
01 Summary
A peptide made by your mitochondria rather than your nuclear DNA. In animal studies it improves how the body handles sugar and responds to exercise — hence the “exercise mimetic” nickname.
02 How it works
MOTS-c activates AMPK, the cell’s energy sensor — the same switch exercise flips. In mice this improved insulin sensitivity, protected against diet-induced weight gain and boosted physical capacity. Natural levels rise with exercise and fall with age.
03 Common uses
04 Run profile
A gentle first week, a step up over the first month, then held. Three times a week, in the morning or before training, in twelve-week blocks.
The profile shows the shape. Ask for the numbers for your vial, your goal and your timeline.
05 Pairs well with
06 What to watch for
Injection-site irritation; some people report palpitations, trouble sleeping or mild stomach upset, and temporary fatigue or heavy legs in the first couple of weeks. Any palpitations, chest discomfort or irregular heartbeat — stop and get checked. Dose in the morning rather than late.
07 Evidence & status
Not approvedCompelling in animals; human research is at an early stage.
Not FDA-approved. Recommended for the 503A compounding list by an FDA advisory panel in July 2026 — non-binding, no decision yet.
08 FAQ
Does it replace exercise?
No. It is called an exercise mimetic because it flips one of the same switches, not because it replaces training.
Why mornings?
Some people find it energising enough to disturb sleep if taken late.
Is the early fatigue normal?
Many report heavy legs for the first week or two while adapting. If it persists, ask.
Educational information only — not medical advice. The Daily Stack does not sell or supply any products. Talk to a licensed healthcare professional about your own health decisions.